cellular biology

Pyk2 and megakaryocytes regulate osteoblast differentiation and migration via distinct and overlapping mechanisms

Osteoblast differentiation and migration are necessary for bone formation during bone remodeling. Mice lacking the proline-rich tyrosinekinase Pyk2 (Pyk2-KO) have increased bone mass, in part due to increased osteoblast proliferation. Megakaryocytes …

C-Mpl is expressed on osteoblasts and osteoclasts and is important in regulating skeletal homeostasis

C‐Mpl is the receptor for thrombopoietin (TPO), the main megakaryocyte (MK) growth factor, and c‐Mpl is believed to be expressed on cells of the hematopoietic lineage. As MKs have been shown to enhance bone formation, it may be expected that mice in …